Back Cover: Antiprotozoal Structure–Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action (Angew. Chem. Int. Ed. 28/2021)

Leucinostatins are fascinating natural substances, with high potency against many pathogens, but their acute toxicity has prevented therapeutic use. Michael Adams, Rainer Riedl, and co-workers demonstrate in the Research Article on page 15613 how these can be converted into synthetically more accessible selective antiprotozoal agents broad efficacy undetectable resistance.